It is indicated for severe pains and fever.

Propacetamol hydrochloride is hydrolysed to paracetamol(acetaminophen) in the plasma for the treatment of pain and fever. Acetaminophen may act predominantly by inhibiting prostaglandin synthesis in the central nervous system (CNS) and through a peripheral action by blocking pain-impulse generation.

Duration: 4-6 hours; Metabolism: At normal therapeutic dosages, hepatic to sulfate and glucuronide metabolites, while a small amount is metabolized by CYP to a highly reactive intermediate (acetylimidoquinone) which is conjugated with glutathione and inactivated; at toxic doses (as little as 4 g daily) glutathione conjugation becomes insufficient to meet the metabolic demand causing an increase in acetylimidoquinone concentration, which may cause hepatic cell necrosis. Elimination half-life:Neonates: 2-5 hours; Adults: 1-3 hours

Hypersensitivity to acetaminophen or any component of the formulation

B

Infant risk is minimal.

Dizziness (most common), Rash

The usual dose is 1-2 g （equivalent to 0.5-1 gm acetaminophen）every 4-6 hours by intravenous infusion over 15 minutes. The maximum daily dose should not exceed 8 g. Pediatrics (neonates and children): 20 to 30 mg/kg up to 4 times daily, not exceeding a maximum daily dose of 120 mg/kg propacetamol (equivalent to a daily dose of 60 mg/kg of paracetamol)

開瓶後應ㄧ次使用完畢，不得分次注射。
每vial稀釋液體積：請以所附的專用溶劑（5 ml）溶解
靜脈輸注液：Normal saline
給藥濃度：in 60-125 ml Normal saline （因此藥之滲透壓高）
給藥速率：IV infusion 15 min
注意事項：調配後必須於30分中內使用；不可和其他藥物混合