Analgesic and antipyretic actions similar to aspirin, no anti-inflammatory properties

Analgesic, Nonopioid

Onset of action: <1 hour
Duration: 4-6 hours (analgesia), >6hours (antipyretic)
Distribution: ~1L/kg
Protein binding: 10%-25% at therapeutic concentrations
Metabolism: At normal therapeutic dosages, primarily hepatic metabolism to sulfate and glucuronide conjugates, while a small amount is metabolized by CYP2E1 to a highly reactive intermediate, N-acetyl-p-benzoquinone imine (NAPQI), which is conjugated rapidly with glutathione and inactivated to nontoxic cysteine and mercapturic acid conjugates.
Excretion: Urine (<5% unchanged; 60% to 80% as glucuronide metabolites; 20% to 30% as sulphate metabolites; ~8% cysteine and mercapturic acid metabolites)

Hypersensitivity to acetaminophen or any component of the formulation; severe hepatic impairment or severe active liver disease

Acetaminophen is recommended to be used at the lowest effective dose for the shortest duration of time to effectively treat the mother and protect the health of the fetus

Considered compatible with breastfeeding when used in usual recommended doses

Erythema of skin, Skin blister, Skin rash, Hearing loss

325 to 650 mg every 4 to 6 hours as needed or 1 g every 6 hours as needed; maximum dose: 4 g/day

10 to 15 mg/kg/dose every 4 to 6 hours as needed; maximum daily dose: 75 mg/kg/day not to exceed 4,000 mg/day

No dosage adjustment necessary

For short-term or one-time use, a maximum of 4 g/day may be considered in lower risk patients with chronic liver disease or early-stage compensated cirrhosis who are not actively drinking alcohol