【缺藥訊息】 公告日期：2024/10/11。 缺藥品項：Actos 錠 30 mg 缺藥原因：廠商供貨不及 配套措施：用罄關檔停用，院內有同成分規格品 Anxotos 錠 30 mg 替代。 【藥品性質提示】 根據 2019 AGS Beers Criteria，本藥品為【潛在不適當用藥 (PIM)】，不建議用於心衰竭之老年人。

Type II diabetes mellitus alone or in combination with sulfonylureas, metformin, or insulin

Pioglitazone is a thiazolidinedione antidiabetic agent.

Total protein binding is greater than 99%; pioglitazone is bound primarily to serum albumin. Pioglitazone is metabolized extensively in the liver to active and inactive metabolites.

Type I diabetes mellitus; diabetic ketoacidosis; pioglitazone should not be started in patients with clinical evidence of active liver disease or in patients with an alanine aminotransferase greater than 2.5 times the upper limit of normal

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Infant risk cannot be ruled out.

The primary adverse effect is edema. Other adverse effects include headache, myalgia, and upper respiratory infection. Although the incidence of liver enzyme elevations was similar for pioglitazone and placebo, and no symptoms of hepatotoxicity were reported, frequent monitoring of liver enzymes is recommended during pioglitazone therapy.

initial dosage 15-30 mg PO QD without regard to meals; the maximum recommended dosage is 45 mg PO QD