#特殊劑型：不建議磨粉、管灌藥品

1. Disease of respiratory system, chronic, with abnormal, viscid, or inspissated mucous secretions
2.Acetaminophen poisoning

Acetylcysteine exerts its mucolytic action through its free sulfhydryl group, which opens the disulfide bonds and lowers mucus viscosity. Acetylcysteine may protect against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione. Glutathione is required to inactivate an intermediate metabolite of acetaminophen that is thought to be hepatotoxic

Time to peak, plasma: Oral: 1-2 hour; Protein-binding: 83%; Metabolism: deacetylated by the liver to cysteine or oxidation to diacetylcystine and subsequently metabolized; Excretion: Renal: 22-30%, Fecal: 3%; Elimination half-life: adults: 5.6 hr, newborns: 11hrs

hypersensitivity or previous anaphylactoid reactions to acetylcysteine or any components in the preparation

B

Excretion in breast milk unknown/use caution

Pruritus, rash, urticaria, nausea, vomiting, bronchospasm

1. Disease of respiratory system with viscid, or inspissated mucous secretions: Adult & children > 6 years: 1 effervescent tab daily or twice daily. Before administration, disperse the effervescent tablet in water, using a drinking glass. 2.Acetaminophene poisoning: initial, 140 mg/kg ORALLY, then 70 mg/kg every 4 hr for 17 doses starting 4 hr after loading dose.