Acute respiratory distress syndrome : To correct interstitial pulmonary edema (in combination with diuretics) and hypoproteinemia associated with acute respiratory distress syndrome. Cirrhotic ascites, therapeutic paracentesis (adjunctive agent):To maintain intravascular volume following removal of large-volume paracentesis in cirrhotic patients. Hypovolemia:Plasma volume expansion and maintenance of intravascular volume in select patients for the treatment of hypovolemia (with or without shock). For replacement of volume deficit, 5% solution is generally preferred. Neonatal hemolytic disease:Binds and detoxifies unconjugated bilirubin in severe hemolytic disease of the newborn during exchange transfusion. Nephrosis (acute) (adjunctive agent):Treatment of edema in patients with acute nephrosis in combination with diuretics. Ovarian hyperstimulation syndrome, treatment :As a plasma volume expander in fluid management for the treatment of severe ovarian hyperstimulation syndrome. Plasma exchange, therapeutic::To avoid excessive hypoproteinemia, during certain types of exchange transfusion, or with the use of very large volumes or previously frozen or washed red cells.
藥理
Blood Product Derivative; Plasma Volume Expander, Colloid: Provides increase in intravascular oncotic pressure and causes mobilization of fluids from interstitial into intravascular space
藥動學
Half-life Elimination:15 to 20 days
禁忌症
Hypersensitivity to albumin or any component of the formulation; severe anemia, heart failure; patients at risk of volume overload (eg, patients with kidney insufficiency, severe anemia, stabilized chronic anemia, or heart failure); dilution with sterile water for injection (may cause hemolysis or acute kidney failure)
懷孕分類
Use in pregnant patients may be considered when contraindications to nonprotein colloids exist
哺乳分類
1.Endogenous albumin is present in breast milk. 2.According to the manufacturer, the decision to breastfeed during therapy should consider the risk of infant exposure, the benefits of breastfeeding to the infant, and benefits of treatment to the mother.
Usual dose: 25 g; initial dose may be repeated in 15 to 30 minutes if response is inadequate. Adult respiratory distress syndrome: 25 g over 30 minutes (in combination with furosemide); may repeat at 8 hours (if necessary) for 3 days Cirrhotic ascites, therapeutic paracentesis (adjunctive agent): 5 to 10 g for every liter removed (usual dose cited: 8 g for every liter removed) or 50 g total for paracentesis >5LHypovolemia: Initial: 12.5 to 25 g (250 to 500 mL)repeat after 15 to 30 minutes as needed (if hemodynamic stability is not achieved). Ovarian hyperstimulation syndrome: IV: 50 to 100 g over 4 hours; repeat at 4 to 12 hours intervals as needed.
小兒調整劑量
Should be used in patients with fluid or sodium restrictions (eg, patients with hypoproteinemia and generalized edema, or nephrotic syndrome). Dose depends on condition of patient.
腎功能調整劑量
There are no dosage adjustments provided in the manufacturer's labeling; use with caution.
肝功能調整劑量
There are no dosage adjustments provided in the manufacturer's labeling; use with caution.