Fexofenadine is a second-generation, long lasting H1-receptor antagonist (antihistamine) which has a selective and peripheral H1-antagonist action.
藥動學
Onset of action: 60 minutes; Duration: antihistaminic effect: ≧12 hours; plasma protein binding: 60-70%; Elimination Half- life: 14.4 hours( prolonged in renal impairment ); Excretion: feces (~80%) and urine (~11%) as unchanged form. Not effectively removed by hemodialysis.
禁忌症
Hypersensitivity to fexofenadine or any component of the formulation
懷孕分類
C
哺乳分類
Excretion in breast milk unknown/use caution (AAP rates “compatible”)
副作用
dizziness, headache, drowsiness, fatigue, vomiting (children 6 months to 5 years: 4% to 12%)
劑量和給藥方法
Adults and children(>12 years) with normal function: 60 mg orally twice daily or 180 mg once daily with water. Children 2-11 years: 30 mg twice daily. Do not take concurrently or closely in time with aluminum and magnesium containing antacids
小兒調整劑量
腎功能調整劑量
Dose adjustments according to ClCr (ml/min), Adults and children (>12 years): 41-80 ml/min, 60 mg QD; <40 ml/min, 30 mg QD.