治療輕度至中度急性潰瘍性結腸炎及其持續治療以防止復發。

5-Aminosalicylic Acid Derivative

Absorption: ~20% to 28%.
Metabolism: hepatic and via GI tract to N-acetyl-5-aminosalicylic acid.
Half-life elimination: ~ 25 hours (range: 2 to 296 hours).
Time to peak, serum: ~24 hours (mean).
Excretion: Urine, feces.

Hypersensitivity to mesalamine, aminosalicylates, salicylates, or any component of the formulation; Severe renal impairment (GFR <30 mL/minute/1.73 m ㎡); severe hepatic impairment.

B

>10%: abdominal pain (1% to 21%), constipation (?11%), eructation (?26%), headache (3% to 14%), nasopharyngitis (children and adolescents: 15%; adults: 1% to 4%).

Acute ulcerative colitis: 4800mg/day or in 2 to 3 divided doses; Maintenance dose: 1600 mg/day.