高血壓 (CCB) 治療心絞痛 vasospastic angina, chronic angina, migraine headache, Raynaud's disease, and hypertension

Nifedipine, a slow-calcium channel antagonist, selectively inhibits the transmembrane influx of calcium ions into cardiac muscle and vascular smooth muscle that is dependent upon for the contractile process

The distribution and elimination half-lives are 2.5 to 3 hours and 3 to 4 hours, respectively.

Hypersensitivity to this or other calcium channel antagonists, advanced aortic stenosis, unstable angina pectoris, acute myocardial infarction (within 4 weeks)

C

Probably safe. Delaying breast feeding by 3-4 hours after a dose would significantly decrease the amount of drug ingested by the infant.

Dizziness, headache, peripheral edema (worse than with verapamil and diltiazem), flushing, rash, and gingival hyperplasia are the most common adverse events seen with the dihydropyridine derivative calcium channel antagonists including nifedipine.

angina and hypertension: 10-20 mg PO TID or 30-60 mg extended release PO QD; doses above 180 mg/day regular release or 90-120 mg extended release are not recommended.