【缺藥訊息】 公告日期：2023/7/4。 缺藥品項：Avelox 錠劑 400mg。 缺藥原因：因生產問題缺藥。 替代藥品：國內有同成份規格替代品。 配套措施：採購替代品，庫存量用罄關檔停用，請改用同成分規格替代品 MOS04 Mosflow 膜衣錠 400 mg 替代。

Fluoroquinolone類抗生素; Treatment of mild to moderate community-acquired pneumonia, acute bacterial exacerbation of chronic bronchitis, acute bacterial rhinosinusitis, skin and skin structure infections, intra-abdominal infections, prophylaxis and treatment of plague.

Antibiotic, Fluoroquinolone
A broad spectrum of antimicrobial activity including G(+) and G(-) organisms, Chlamydia spp, anaerobes, and Mycobacterium tuberculosis. It inhibits bacterial DNA topoisomerases required for bacterial DNA replication, transcription, repair, and recombination.

1. Bioavailability: approximately 90%
2. Protein binding 50%
3. Metabolism: metabolized in liver via glucuronide and sulfate conjugation, 15~21% unchanged renal excretion, t1/2 9~16 hr

Hypersensitivity to moxifloxacin or quinolones

C

Avoided

Nausea, diarrhea, hypertension, palpitation, QT interval prolongation, skin rash

Oral: can be given concurrently with food; but not with antacids containing magnesium or aluminum or preparations containing sucralfate, metal cations such as iron, or zinc; Oral doses should be given at least 4 hours before or 8 hours after antacids.

1. Altered kidney function: No dosage adjustment necessary
2. Hemodialysis, Peritoneal dialysis, CRRT: Poorly dialyzed; No supplemental dose or dosage adjustment necessary

No dosage adjustment necessary; however, use with caution in this patient population secondary to the risk of QT prolongation.