Benign prostatic hyperplasia(BPH) in men with an enlarged prostate

Dutasteride inhibits the conversion of testosterone to 5α-dihydrotesterone (DHT). Testosterone is converted to DHT by the enzyme 5-α-reductase, which exists as isoforms, type1 and type2. Dutasteride is an irreversible competitive inhibitor of 5-α-reductase type1 and type2.

Bioavailability is approximately 61%. Dutasteride is highly bound to plasma albumin (99%) and alpha-1 acid glycoprotien (99.6%). Dutasteride is extensively metabolized in liver via CYP3A4 isozymes, and its metabolites were excreted mainly in feces. The terminal elimination half- life is approximately 5 weeks at steady state. Dutasteride is absorbed via skin when handling capsules.

use in women and children, hypersensitivity to dutasteride, or other 5-α-reductase inhibitors, or any component of the preparation.

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Serum testosterone increased, thyroid-stimulating hormone increased, impotence, decreased libido, ejaculation disorder, breast tenderness and breast enlargement.

0.5mg taken orally once a day. The capsules should be swallowed whole. May be administered with or without food.