用於先天性缺乏維生素K凝血因子或因接受維生素K拮抗劑治療之出血。

Antihemorrhagic agent, blood coagulation factor 2, 7, 9, 10 composition

Onset of action: Rapid (significant INR decline within 10 minutes).
Duration: ~6 to 8 hours.
Distribution: Vdss: Factor II: 71.4 mL/kg; Factor VII: 45 mL/kg; Factor IX: 114.3 mL/kg; Factor X: 55.5 mL/kg; Protein C: 62.2 mL/kg; Protein S: 78.8 mL/kg.
Half-life elimination: Factor II: 48 to 60 hours; Factor VII: 1.5 to 6 hours; Factor IX: 20 to 24 hours; Factor X: 24 to 48 hours; Protein C: 1.5 to 6 hours; Protein S: 24 to 48 hours.

Hypersensitivity to prothrombin complex concentrate (PCC) or any component of the formulation; disseminated intravascular coagulation (DIC); heparin-induced thrombocytopenia

C

< 10%: hypotension (5 - 7%), tachycardia (3 - 5%), atrial fibrillation (4%), intracranial hemorrhage (3%), mental status changes (3%), hypervolemia (1 - 6%), hypokalemia (2 - 5%), nausea and vomiting (4 - 6%), anemia (3% to 6%), prolonged bleeding time (4%), antibody development (3%), arthralgia (4%), pleural effusion (4%), respiratory distress (2 - 4%).

所需劑量=體重〔kg〕× 希望增加的因子﹝IU/ml﹞× 53
1 IU 第九因子/每公斤體重，預計會提高血漿第九因子活性為正常量的 1.3% (0.013 IU/ml)。
1 IU 第七因子/每公斤體重，會提高血漿第七因子活性為正常量的 1.7 % (0.017 IU/ml)。
1 IU 第二因子/每公斤體重，會提高血漿第二因子活性為正常量的 1.9 % (0.019 IU/ml)。
1 IU 第十因子/每公斤體重，會提高血漿第十因子活性為正常量的 1.9 % (0.019 IU/ml)。

同成人