解毒劑 Cellular rescue from the adverse effects of high-dose methotrexate therapy

Calciumfolinate is used to diminish the toxicity and counteract the effect of high doses of folic acid antagonists

Bioavailability: (calciumfolinate) 97% for 25 mg, 75% for 50 mg, 37% for 100 mg, and 31% for 200 mg
Metabolism: intestinal mucosa and hepatically to 5-methyl-tetrahydrofolate (active)
Elimination half-life: 4-8 hrs

Pernicious anemia and other megaloblastic anemia secondary to lack of Vitamin B12

C

Excretion in breast milk unknown/use caution

Occasional allergic reactions

High-dose methotrexate-rescue:
Initial 15mg (10 mg/m²); start 8-24 hrs after beginning methotrexate infusion; continue every 6 hrs for 10 doses, until methotrexate level is <0.05 mmol/L
Folic acid deficiency:
10-20mg/day; common dose: 1 tablet/day

Folic acid deficiency:
(Children <12y/o) 0.25mg/kg/day

Unknown

Unknown