Cephalosporins類抗生素 (三四代)

1. Upper and lower respiratory and urinary tract infections
2. Skin, soft tissue, bone and joint infections
3. Septicemia, meningitis, peritonitis, cholecystitis, cholangitis, pelvic inflammatory disease, endometritis, gonorrhea, and other abdominal and genital tract infections.
#仿單變更2021

Cephalosporin antibiotic

Distribution:
Protein binding: Cefoperazone 82-93%；Sulbactam 38%
Metabolism:
Cefoperazone/Sulbactam almost cannot be metabolized
Elimination:
Cefoperazone (bile/kidney) 20-30%; Sulbactam (urine) 75-85%

Hypersensitivity to cephalosporins

B (FDA)

Infant risk cannot be ruled out (MDX)

Common: Diarrhea, pruritus, fever, increased AST or ALT
Severe/Postmarketing:
1. Hypersensitivity reactions (including anaphylaxis)
2. Acute renal dysfunction
3. Pseudomembranous colitis
4. Interstitial lung disease, pulmonary infiltration with eosinophilia (PIE)
5. Severe skin reaction: Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN), Acute Generalized Exanthematous Pustulosis (AGEP) <20211130>
6. Haemolytic anemia, pancytopenia, agranulocytosis, thrombocytopenia
7. Fulminant Hepatitis
8. Hemorrhage: prolonged prothrombin times, thrombocytopenia <20211130>
9. Vitamin-K deficiency, abnormal coagulation <20211130>

Usual dose:
(IV, IM)The total adult daily dose is 1g/1g to 2g/2g, and divided into two times (every 12 hours) .
Severe infections:
may increase to 4g/4g per day , and divided into two times (every 12 hours).

Usual dose:
20mg/20mg (Cefoperazone/Sulbactam) to 40mg/40mg (Cefoperazone/Sulbactam) per kilogram a day, and divided into two to four times.
Severe infections:
may increase to 80mg/80mg per kilogram a day, and divided into two to four times.

1. Ccr>30mL/min: 4g/4g (2g/2g every 12 hours).
2. Ccr 15-30mL/min: 2g/2g (1g/1g every 12 hours).
3. Ccr ≦15mL/min: 1g/1g (500mg/500mg every 12 hours).

Store at room temperature