治療心律不整 治療心衰竭 Congestive heart failure, atrial fibrillation, atrial flutter, paroxysmal atrial tachycardia, cardiogenic shock.

Digoxin inhibits sodium-potassium ATPase, which increases intracellular sodium concentration leading to increased intracellular calcium concentration. Autonomic effects of this include vagomimetic action and baroreceptor sensitization which lead to positive inotropic action, reduced sympathetic response and decreased renin-angiotensin system output (neurohormonal deactivation)

Bioavailability, oral solution: 70% to 85%; Protein binding: 25%; Vd: 475 to 500 L ( hyperthyroidism: Increased, hypothyroidism: Decreased. Metabolism- Hepatic: 13%, not CYP450-dependent; Excretion-Renal: 50% to 70% unchanged, Fecal: 3% to 5%, Biliary: 6% to 8%, Dialyzable: No (hemodialysis, peritoneal); Elimination Half Life: 1.5 to 2 days (Anuric patients: 3.5 to 5 days)

Ventricular fibrillation, digitalis intoxication.

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Although limited experience, the data is lacking association between the drug and congenital defects.

Safe; the milk/plasm ratio have varies from 0.6-0.9. No adverse effects in the nursing infant have been reported

GI disturbance, anorexia (the earliest symptom of digoxin overdose), cardiac arrhythmia, and conduction defect.

Adults: Oral: rapid digitalization: 0.75-1.5mg, maintenance dose: 0.125-0.25mg; Infants and Children: 10-20ug/kg/day by mouth Heart failure (Oral solution) Loading dose, first dose: Give half the total loading dose; for subsequent doses as clinically indicated, give additional fractions of the total loading dose at 4- to 8-hour intervals; total oral loading dose: (premature) 20 to 30 mcg/kg; (full term) 25 to 35 mcg/kg; (1 to 24 months) 35 to 60 mcg/kg; (2 to 5 years) 30 to 45 mcg/kg; (5 to 10 years) 20 to 35 mcg/kg; (older than 10 years) 10 to 15 mcg/kg (Oral solution) Maintenance dosage, (premature) 2.3 to 3.9 mcg/kg twice daily; (full term) 3.8 to 5.6 mcg/kg twice daily; (1 to 24 months) 5.6 to 9.4 mcg/kg twice daily; (2 to 5 years) 4.7 to 6.6 mcg/kg twice daily; (5 to 10 years) 2.8 to 5.6 mcg/kg twice daily; (older than 10 years) 3 to 4.5 mcg/kg once daily

Renal impairment: dose adjustment necessary