【藥品性質提示】 根據 2019 AGS Beers Criteria，本藥品為【潛在不適當用藥 (PIM)】，不建議用於心衰竭(射出率下降)之老年人。

治療心律不整 治療心絞痛 高血壓 (CCB) Treatment of coronary artery spasm, angina pectoris, essential hypertension, supraventricular arrhythmia

Diltiazem hydrochloride is a slow calcium channel blocker that blocks calcium ion influx during depolarization of cardiac and vascular smooth muscle. It decreases peripheral vascular resistance and causes relaxation of the vascular smooth muscle resulting in a decrease of both systolic and diastolic blood pressure

Distribution:
1. Vd: 305 L to 391 L
2. Protein binding: 70% to 80%
Metabolism:
Hepatic; cytochrome P450, extensive, deacetylation, N-demethylation, O-demethylation, and conjugation
Excretion:
1. Fecal, Renal: 2% to 4% unchanged
2. Dialyzable: no (hemodialysis or peritoneal dialysis)

Hypersensitivity to diltiazem, Cardiogenic shock, Heart block, second or third-degree atrioventricular without a functioning ventricular pacemaker.

C

Avoided, the level in milk is similar to those of maternal serum level; The American Academy of Pediatrics considers it to be compatible with breast- feeding.

A-V nodal block, hypotension, headache, and GI disturbance.

30-50mg TID, maximum 360 mg/day divided into 3-4 doses