【缺藥訊息】 公告日期：2024/7/17。 更新日期：2024/8/7 缺藥品項：Catapres 錠劑 75 mcg 缺藥原因：工廠製造不及導致短暫缺貨 替代藥品：無同成分規格健保替代藥 配套措施：本品預計恢復供貨時間未知，將保留慢箋量供現有病人使用，新病人請改用其他藥品。

高血壓 (其他) All grades of hypertension, prophylaxis of migraine, recurrent vascular headache.

Besides antihypertension, clonidine has been used as other therapeutics: epidural injection for cancer pain; symptomatic control of alcohol, benzodiazepine, nicotine, or opiate withdrawal; analgesia during surgery; alternative to estrogen for menopausal symptom control; migraine prophylaxis; diagnostic tool in pheochromocytoma and the growth hormone screening test; attention-deficit hyperactivity disorder or other anxiety-related disorders; autonomic dysfunction induced chronic diarrhea.

Tmax, Oral: 2.07 to 5 hours, immediate-release; Bioavailability, 75% to 100%; Distribution - Vd: 2.1 L/kg, Protein binding: 20% to 40%; Metabolism- Hepatic: 50%; Excretion - Fecal: 22%, Renal: 40% to 60% unchanged, Dialyzable: No (hemodialysis); Elimination Half Life: Adults, oral: 12.5 to 16 hours, Adults, renal impairment: up to 41 hours.

Hypersensitivity; sick sinus syndrome; Concomitant administration of tricyclic antidepressants may decrease its antihypertensive effect.

C

Avoided, although no adverse effect in infant has been reported, the level in breast milk may reach twice those of maternal serum level. A decreasing prolactin secretion has been reported.

Dry mouth, drowsiness, and sedation.

Initial dose: 0.05-0.1mg TID or QID gradually increase until desired response is achieved. Usual maintenance dose: 0.2-1.2mg/day, maximum dose: 2.4mg/day; Reduce the dosage should be gradually over a 2-4 days period to avoid sudden hypertension, or cerebral phenomenon.