【藥品訊息】 勝克敏液 仿單

Perennial and seasonal allergic rhinitis and other allergic symptoms including urticaria; chronic idiopathic urticaria

Cetirizine, a metabolite of hydroxyzine, is H1-receptor antagonist with minimal anticholinergic or central nervous system activity

Onset of action: 15-30 minutes; plasma protein binding: 93%; Elimination Half-life: 8 hours; Excretion: Urine (70%); feces (10%)

Hypersensitivity to cetirizine or hydroxyzine; Avoid concurrent use of central nervous system depressants or patient with renal insufficiency or hepatic dysfunction.

Fetal risk cannot be ruled out.

Enters breast milk/not recommended

Headache, somnolence, fatigue, and dry mouth are the common side effects. Doses greater than 10 mg may be associated with a higher frequency of side effects, especially sedation.

Dosage adjustment in renal impairment:
◎ Children <6 years: Cetirizine use not recommended
◎ Children 6-11 years: <2.5 mg once daily
◎ Children ≥12 and Adults:

1. CrCl 11-31 mL/minute, hemodialysis: 5 mg once daily
2. CrCl <11 mL/minute, not on dialysis: Cetirizine use not recommended

Dosage adjustment in hepatic impairment:
◎ Children <6 years: Cetirizine use not recommended
◎ Children 6-11 years: <2.5 mg once daily
◎ Children ≥12 and Adults: 5 mg once daily