【缺藥訊息】 公告日期：2023/12/21。 缺藥品項：Clomiphene 錠劑 50mg。 缺藥原因：因生產問題缺藥。 替代藥品：國內有同成份規格替代品。 配套措施：採購替代品，庫存量用罄關檔停用，替代品預計於2024/1/17到貨 (依照實際到貨日為準)。

It is used in anovulatory infertility; the drug has also been used to treat male infertility.

Clomiphene citrate, a nonsteroidal ovulatory stimulant, is suggested to interact with estrogen-receptor-containing tissues by competing with estrogen for estrogen-receptor-binding sites and delaying the replenishment of estrogen receptors in cells. It has estrogenic and antiestrogenic properties that may contribute to initiation of ovulation with no apparent progestational, androgenic and antiandrogenic effects.

Absorption: Oral readily absorbed; Excretion - Fecal: 42% (mean), Fecal and Renal: (Oral), 50%, Dialyzable: unknown

During pregnancy; liver dysfunction; abnormal uterine bleeding; organic intracranial lesion such as a pituitary tumor; uncontrolled thyroid or adrenal dysfunction; hypersensitivity to clomiphene

X

Avoided

Hot flushes, abdominal discomfort, ovarian enlargement, blurred vision; isolated cases of cancer (testicular, hepatic, breast) have been reported.

50mg/day for 5 days should be started in the fifth day of the cycle; if no effect, next course 100mg/day for 5 days.