Induce ovulation in infrequently ovulating or anovulatory women, including patients with polycystic ovary syndrome (PCOS).

Ovulation Stimulator; Selective Estrogen Receptor Modulator (SERM)
Clomiphene is a non-steroidal compound with weak estrogenic and moderate antiestrogenic properties.It induces ovulation by increasing the output of pituitary gonadotropins. The decreased binding of endogenous estrogen to hypothalamic and pituitary estrogen receptors results in increased secretion of luteinizing hormone-releasing hormone (LH-RH) and follicle-stimulating hormone-releasing hormone (FSH-RH) followed by the gonadotropins LH and FSH

Absorption: Readily absorbed.
Metabolism: Hepatic; undergoes enterohepatic recirculation.
Half-life elimination: ~5 days.
Excretion: Primarily feces (42%); urine (8%).

During pregnancy; liver dysfunction; abnormal uterine bleeding; organic intracranial lesion such as a pituitary tumor; uncontrolled thyroid or adrenal dysfunction; hypersensitivity to clomiphene.

Avoided

Ovary enlargement,Headache, Hot flash, Abdominal discomfort,Visual disturbance

50 mg once daily for 5 days. Begin on or about the fifth day of cycle.

Use is contraindicated in patients with a history of liver disease or dysfunction.