高血壓 (Beta-blocker) 治療心衰竭 治療心絞痛 Angina pectoris, Congestive heart failure, Hypertension
#仿單變更2021

Bisoprolol is a selective inhibitor of beta1-adrenergic receptors; competitively blocks beta1-receptors, with little or no effect on beta2-receptors at doses ?20 mg.

Onset of action: 1-2 hrs; Bioavailability: about 80%; Plasma protein binding: 30%; Metabolism: Extensively hepatic; significant first-pass effect (~20%); Elimination half-life: normal renal function: 9-12 hrs; Clcr <40 ml/min: 27-36 hrs; Hepatic cirrhosis: 8-22 hrs; Excretion: Urine (50% as unchanged drug, remainder as inactive metabolites); feces (<2%)

Cardiogenic shock; overt cardiac failure; marked sinus bradycardia; heart block greater than first-degree (except in patients with a functioning artificial pacemaker)

C

Excretion in breast milk unknown/use caution

Dizziness (10%), headache (11%), bradyarrhythmia (9%), cold extremities, hypotension, fatigue (dose related; 6% to 8%), insomnia, diarrhea (dose related; 3% to 4%), nausea, vomiting.
Postmarketing: dermatitis, angioedema<20210223>

Angina pectoris, chronic: 5-20 mg ORALLY once daily; Congestive heart failure: initial, 1.25 mg once daily, titrate to maximum dose of 10 mg once daily; Hypertension: initial, 2.5-5 mg once daily, maximum dose, 40 mg once daily.