Treatment of glaucoma; lower high eye pressure
#仿單變更2022

Dorzolamide: Carbonic Anhydrase Inhibitor
Inhibits carbonic anhydrase in the ciliary processes of the eye resulting decreased bicarbonate ion formation which decreases sodium and fluid transport, thus reducing intraocular pressure.
Timolol: Nonselective Beta-Blocker
Blocks both beta1- and beta2-adrenergic receptors, reduces intraocular pressure by reducing aqueous humor production or possibly increases the outflow of aqueous humor.

1. Hypersensitivity to dorzolamide, timolol, or any component of the formulation
2. Bronchial asthma or a history of bronchial asthma
3. Severe chronic obstructive pulmonary disease
4. Sinus bradycardia; second- or third-degree AV block; overt cardiac failure; cardiogenic shock

C

Use is not recommended

Dysgeusia, burning sensation of eyes, stinging of eyes, blurred vision, conjunctival hyperemia, eye pruritus, superficial punctate keratitis, foreign body sensation of eye, hallucination, dyspnea, palpitation <20220414>

One drop in affected eye(s) twice daily

1. CrCl ≥30 mL/minute: No dosage adjustment necessary
2. CrCl <30 mL/minute: Use is not recommended (has not been studied)

There are no dosage adjustments provided in the manufacturer's labeling (has not been studied); use with caution.