Ancylostoma duodenale or Necator americanus、Ascariasis、Capillariasis、Echinococcus, cystic、Enterobiasis、Toxocariasis、Trichinellosis、Trichostrongyliasis、Trichuriasis

Anthelmintic

Absorption: Oral: Poor; 5% to 10%; increased with food
Distribution: Vd: 1 to 2 L/kg
Protein binding: 90% to 95%
Metabolism: Extensively hepatic
Half-life elimination: 3 to 6 hours
Excretion: Primarily feces (as unchanged drug and primary metabolite); urine (<2%)

Hypersensitivity to mebendazole or any component of the formulation

Information following first trimester exposure to mebendazole is limited; however, an increased risk of birth defects has not been observed in the available studies (Gyorkos 2019). Most pregnancy outcome information is available from studies using mebendazole during the second or third trimester (Akpan 2018; Gyorkos 2019).
Untreated soil-transmitted helminth infections during pregnancy are associated with adverse maternal outcomes (eg, maternal iron deficiency anemia, low birth weight, neonatal and maternal death).
The World Health Organization (WHO) recommends preventive therapy with a benzimidazole, such as mebendazole, in pregnant women after the first trimester who live in areas where the baseline prevalence of soil-transmitted helminth infections is 20% (WHO 2017). The WHO also recommends treatment of soil-transmitted helminthiases (such as hookworm) in pregnant patients after the first trimester (WHO 1996).

According to the manufacturer, the decision to continue or discontinue breastfeeding during therapy should take into account the risk of infant exposure, the benefits of breastfeeding to the infant, and benefits of treatment to the mother. However, mebendazole is generally considered compatible with breastfeeding.

Gastrointestinal: Abdominal pain, anorexia, diarrhea, flatulence, nausea, vomiting
Hepatic: Hepatitis

1. Ancylostoma duodenale or Necator americanus (hookworm):
Oral: 100 mg twice daily for 3 days (manufacturer's labeling; CDC 2018b) or 500 mg as a single dose (CDC 2018b). Repeat in 3 weeks if not cured with initial treatment.
2. Ascariasis (roundworm):
Oral: 100 mg twice daily for 3 days or 500 mg as a single dose. Repeat in 3 weeks if not cured with initial treatment.
3. Capillariasis (off-label use):
Oral: 200 mg twice daily for 20 days.
4. Echinococcus, cystic (alternative agent) (off-label use):
Oral: 40 to 50 mg/kg/day in 3 divided doses for 3 to 6 months.
5. Enterobiasis (pinworm):
Oral: 100 mg as a single dose (manufacturer's labeling); repeat in 2 weeks.
6. Toxocariasis (off-label use):
Oral: 100 to 200 mg twice daily for 5 days.
7. Trichinellosis ( Trichinella spiralis ) (off-label use):
Oral: 200 to 400 mg 3 times daily for 3 days, followed by 400 to 500 mg 3 times daily for 10 days.
8. Trichostrongyliasis (off-label use):
Oral: 100 mg twice daily for 3 days.
9. Trichuriasis (whipworm):
Oral: 100 mg twice daily for 3 days or 500 mg as a single dose; repeat in 3 weeks if not cured with initial treatment.

1. Ancylostoma duodenale or Necator americanus (hookworm):
Children and Adolescents: Limited data available in children <2 years: Oral: 100 mg twice daily for 3 days or 500 mg once as a single dose; repeat in 3 weeks if not cured with initial treatment.
2. Ascariasis (Ascaris lumbricoides; roundworm):
Children and Adolescents: Oral: 100 mg twice daily for 3 days or 500 mg once as a single dose. Treatment can be repeated in 3 weeks if not cured with initial treatment; the 3-day regimen may be preferred in patients who remain infected after initial treatment.
3. Capillariasis (Capillaria hepatica or Capillaria philippinensis):
Limited data available: Children and Adolescents: Oral: 200 mg twice daily for 20 days.
4. Enterobiasis (Enterobius vermicularis; pinworm):
Children and Adolescents: Limited data available in children <2 years: Oral: 100 mg as a single dose; repeat in 2 weeks.
5. Toxocariasis (roundworm; ocular or visceral larva migrans):
Limited data available: Children and Adolescents: Oral: 100 to 200 mg twice daily for 5 days; however, longer duration may be necessary; optimal duration of treatment unknown.
6. Trichinellosis ( Trichinella species):
Limited data available: Children and Adolescents: Oral: 200 to 400 mg 3 times daily for 3 days, then 400 to 500 mg 3 times daily for 10 days; longer duration or repeat courses may be needed if treatment is not initiated promptly.
7. Trichuriasis (Trichuris trichiura; whipworm):
Children and Adolescents: Limited data in children <2 years: Oral: 100 mg twice daily for 3 days; repeat in 3 weeks if not cured with initial treatment.

There are no dosage adjustments provided in the manufacturer's labeling.

There are no dosage adjustments provided in the manufacturer's labeling; however, undergoes extensive hepatic metabolism and systemic exposure may be increased; use with caution.

store under 25℃ and away from light.