【缺藥訊息】 公告日期：2024/1/12。 缺藥品項：Cymevene 針 500mg/10mL/Vial。 缺藥原因：因產程問題缺貨。 替代藥品：國內有同成份規格替代品。 配套措施：庫存量用罄關檔停用，請改用同類藥品 (Valcyte 錠劑 450 mg) 替代，本品預計 2024/4 恢復供貨。

抗病毒藥品
1. Prevention of cytomegalovirus (CMV) disease in transplant recipients adult
2. Treatment of CMV retinitis in immunocompromised adult (including patients with AIDS)

Antiviral Agent
Ganciclovir is phosphorylated by viral and cellular kinases into ganciclovir triphosphate which competitively inhibits the binding of deoxyguanosine triphosphate to DNA polymerase resulting in inhibition of viral DNA synthesis.

Distribution:
1. Vd: (adults) 0.74 +/- 0.15 L/kg; (children) 0.64 +/- 0.22 L/kg
2. Protein binding: 1%-2%.
Excretion:
1. Renal: 91.3% +/- 5% unchanged
2. Dialyzable: yes (HD: 50%)
Elimination Half Life:
1. Adults: 3.5 +/- 0.9 hr
2. Renal impairment: 4.4 +/- 0.4 hr to 10.7 +/- 5.7 hr
3. Neonates: 2.4 hr; Pediatric: 2.4 +/- 0.7 hr

Hypersensitivity to ganciclovir, valganciclovir, acyclovir, or any component of the formulation

C (FDA); D(AUS)

Infant risk cannot be ruled out.

Diaphoresis, diarrhea, anorexia, vomiting, thrombocytopenia, leukopenia, anemia, neutropenia, sepsis, retinal detachment, increased serum creatinine, fever, chills, neuropathy, pruritus

Cytomegaloviral retinitis (immunocompromised patients):
1. Immediate sight-threatening lesions: 5 mg/kg/dose every 12 hours for 14 to 21 days followed by chronic maintenance therapy
2. Chronic maintenance therapy: 5 mg/kg/dose once daily (7 days/week) or 6 mg/kg/dose once daily (5 days/week) for 3 to 6 months until sustained CD4 count >100 cells/mm3 in response to antiretroviral therapy
Cytomegalovirus disease prophylaxis in transplant patients:
1. Hematopoietic cell transplant recipients (allogeneic): 5 mg/kg/dose every 12 hours for 5 to 7 days, then 5 mg/kg/dose every 24 hours until day 100 post-transplant
2. Solid organ transplant recipients: 5 mg/kg/dose every 24 hours; duration is dependent on type of transplant, as well as donor and recipient cytomegalovirus (CMV) serostatus

Limited data available

There are no dosage adjustments provided in the manufacturer's labeling (has not been studied).

1. Reconstituted solution is stable for 12 hours at room temperature; do not refrigerate.
2. Keep diluted solution under refrigeration; Do not freeze; Use within 24 hours of dilution to reduce risk of contamination.