First generation Histamine H1 Antagonist
Cyproheptadine hydrochloride is a serotonin and histamine antagonist that competes with serotonin and histamine respectively, for receptor sites. It has also anticholinergic and sedative effects
藥動學
Excretion
Excretion: Fecal: 2% to 20%, 5.7% of the dose unchanged, Renal: 40%
禁忌症
1. Patient with glaucoma
2. Elderly debilitated
懷孕分類
B
哺乳分類
Avoided, significant level present in breast milk and maternal prolactin level found decreased
副作用
Dry mouth, dizziness, drowsiness, nausea and irritability
劑量和給藥方法
Allergy:
4 mg TID (Max 0.5 mg/kg/day) Stimulation of appetite:
2-4 mg TID or QID
小兒調整劑量
Allergy:
1. Children 2- 6 yrs: 2 mg BID or TID (Max 12mg/day)
2. Children 7-14 yrs: 4 mg BID or TID (Max 16 mg/day) Stimulation of appetite:
Children: 2-6 yrs: 2 mg BID or TID (Max 8 mg/day)