Psoriasis vulgaris 尋常性牛皮癬

Daivobet contains calcipotriol 50 mcg/gm and betamethasone dipropionate 0.5mg/gm. Calcipotriol. a synthetic analog of 1,25-dixydroxyvitamin D3, binds to the vitamin D receptor and act as a heterodimer with the retinoid X receptor. Calcipotriol can modulate the inflammatory process in psoriasis by decreasing the levels of interleukin-1 (IL-1) and IL-6 and by reducing the CD45RO and C8+ T cells. Betamethasone dipropionate is a class III potency, synthetic, fluorinated topical steroid.

the systemic absorption of calcipotriol and betamethasone dipropionate from the combination product through normal skin is less than 1%.

1) patients with a history of hypersensitivity to any of the components

2) patients with disorders of calcium metabolism, and

3) patients with erythrodermic, exfoliative, and pustular psoriasis.

C

This product should not be used during pregnancy or lactation unless considered essential by the physician.

The most common: those related to irritation of the skin (lesional/perilesional, pruritus, burning, erythema)

It should be applied once daily on ≦30% of the body surface. Daivobet should not be applied to the face, axillae, groin, or thin skin areas. The maximum dose should not exceed 15 g/day and 100 g/week. The recommended treatment period is 4 weeks.