Penicillin類抗生素

Treatment of systemic infections such as pneumonia, skin and soft tissue infections, and osteomyelitis caused by penicillinase-producing staphylococci

Antibiotic, Penicillin
Active against most Gram (+) organisms and Neisseria spp. Activity is less than other penicillins. Effective to those infections caused by penicilln-resistant Staphylococci and Streptococci.

Absorption:
1. Rate: 60% to 80%; reduced by food
2. Time to peak, serum: 1-2.5hrs
Distribution:
1. Throughout body with highest concentrations in kidney and liver; CSF penetration is low
2. Protein binding: 88% to 98%
Excretion:
Feces, urine (56% to 70% as unchanged drug); Not dialyzable

1. Hypersensitivity to penicillins
2. Used with caution in jaundiced neonates

B

Infant risk is minimal

Nausea, diarrhea, abdominal pain

125-500 mg Q6H; Should not be administered in the supine position or immediately before going to bed

1. Children <40 kg: 12.5-25 mg/kg/day Q6H; doses of 50-100 mg/kg/day Q6H have been used for therapy of osteomyelitis
2. Children >40 kg: 125-250 mg Q6H

1. A reduction in total dosage should be considered in renal impairment.
2. Not dialyzable; supplemental dose is not necessary

There are no dosage adjustments provided in the manufacturer's labeling.