黴菌感染
1. Candidiasis (esophageal, oropharyngeal, peritoneal, urinary tract, vaginal); Systemic candida infections (candidemia, disseminated candidiasis, pneumonia)
2. Cryptococcal meningitis
3. Antifungal prophylaxis in allogeneic hematopoietic cell transplant recipients

Antifungal Agent, Azole Derivative
Interferes with fungal cytochrome P450 activity (lanosterol 14-α-demethylase), decreasing ergosterol synthesis (principal sterol in fungal cell membrane) and inhibiting cell membrane formation

Distribution:
1. Vd: (children age 5 to 15 years) 0.722 to 1.069 L/kg
2. Protein binding: 11% to 12%
Excretion:
1. Renal: approximately 80% unchanged, 11% as metabolite
2. Dialyzable: yes (hemodialysis), 50% removed in 3 hours

1. Hypersensitivity to fluconazole or any component of the formulation (cross-reaction with other azole antifungal agents may occur; use caution)
2. Coadministration with CYP3A4 substrates, which may lead to QTc prolongation (eg, erythromycin, pimozide, quinidine)

D [FDA.AUS]

Infant risk is minimal

Nausea, vomiting, elevation in liver function tests, hypokalemia

Candidemia:
1. For initial therapy: Loading dose of 800 mg (or 12 mg/kg) on day 1, then 400 mg (or 6 mg/kg) once daily; if fluconazole-susceptible Candida glabrata isolated, transition to 800 mg (or 12 mg/kg) once daily
2. Duration: Continue for ≥14 days after first negative blood culture and resolution of signs/symptoms
Cardiac device infection (eg, implantable cardiac defibrillator, pacemaker, ventricular assist device), CNS infection, endocarditis:
400 to 800 mg (or 6 to 12 mg/kg) once daily for 4 to 6 weeks
Esophageal infection:
400 mg (or 6 mg/kg) on day 1, then 200 to 400 mg (or 3 to 6 mg/kg) once daily for 14 to 21 days
Intra-abdominal infection:
800 mg (or 12 mg/kg) on day 1, then 400 mg (or 6 mg/kg) once daily; Total antifungal duration is ≥14 days based on source control and clinical response
Peritonitis:
200 mg on day 1, then 100 to 200 mg once daily for 2 to 4 weeks

Not recommended in children <16 years of age.

1. ClCr >50ml/min: No dosage adjustment necessary
2. ClCr< 50ml/min: 50% of usual daily dose

There are no dosage adjustments provided in the manufacturer's labeling; use with caution.

Store glass bottles between 5 and 30 degrees C (41 and 86 degrees F). Protect from freezing.