止吐口服 (antiemetics PO) Diphenidol is an antiemetic agent. It may be used to treat nausea and vomiting or vertigo.
藥理
Diphenidol is an antiemetic. It exerts effects directly on the chemoreceptor trigger zone in the central nervous system to inhibit nausea and vomiting. It also is reported to influence the vestibular apparatus to control vertigo. It has weak antimuscarinic activity.
藥動學
Bioavailability: well-absorbed; Renal Excretion: 84% to 90%
禁忌症
Patient who has hypersensitivity to the drug. Use with caution to those patient with glaucoma, GI/GU obstruction
懷孕分類
Fetal risk can not be ruled out.
哺乳分類
Infant risk can not be ruled out.
副作用
The most serious side effects are hallucinations, confusion, and disorientation. Diphenidol should only be administered to patients in the institutional setting.
劑量和給藥方法
25-50 mg PO Q4H, diphenidol should Not be used in children weighing less than 23 kg.
小兒調整劑量
腎功能調整劑量
Diphenidol should not be used in patients with anuria.