適用於革蘭氏陽性菌及葡萄球菌引起之感染症。
Indicated for infections caused by Gram-positive bacteria and staphylococci.
Fusidic acid 是細菌蛋白質合成抑制劑,以產生抗菌效果。對部分革蘭氏陽性菌具有強效,尤其是對葡萄球菌有效。
Fusidic acid is a bacterial protein synthesis inhibitor, exerting its antibacterial effect. It is particularly effective against some Gram-positive bacteria, especially staphylococci.
Fusidic acid 經由肝臟代謝,主要經由膽汁排泄,少數或無經由尿液排出。它可穿透組織並廣泛分佈於全身器官。
Fusidic acid is metabolized in the liver and primarily excreted via bile, with little to no renal excretion. It penetrates tissues well and is widely distributed throughout the body's organs.
對 Fusidic acid 過敏者禁用。
Contraindicated in individuals with hypersensitivity to fusidic acid.
動物實驗及臨床經驗顯示缺乏致畸胎的作用,但本品會通過胎盤。因此,在妊娠期最後三個月應避免使用。
English: Animal studies and clinical experience indicate a lack of teratogenic effects, but the drug crosses the placenta. Therefore, it should be avoided during the last three months of pregnancy.
Fusidic acid 在乳汁中的濃度微少,對哺乳婦女無禁忌。
Fusidic acid is present in low concentrations in breast milk, with no contraindications for breastfeeding women.
可能引起腸胃道障礙,如消化不良、噁心、嘔吐、腹瀉。每日劑量1.5-3g可能導致可逆性氨基轉氨酵素增加及可逆性黃疸。
May cause gastrointestinal disturbances such as dyspepsia, nausea, vomiting, diarrhea. Daily doses of 1.5-3g may lead to reversible increases in transaminases and reversible jaundice.
成人與超過12歲之兒童:每日三次,每次二錠。皮膚與軟組織感染建議劑量為每日二次,每次一錠,症狀嚴重者可加倍。
Adults and children over 12 years: 2 tablets three times daily. For skin and soft tissue infections, the recommended dose is 1 tablet twice daily; in severe cases, the dose may be doubled.
未提供具體調整劑量建議。
No specific dosage adjustment recommendations provided for children.
由於 Sodium fusidate 並無顯著的透析效果,對腎功能受損或正在接受血液透析病人不須調整劑量。
No dosage adjustment is necessary for patients with renal impairment or those undergoing hemodialysis as sodium fusidate is not significantly dialyzable.
對於肝功能不全、膽道不正常或同時使用其他經由相同排泄路徑的抗生素之病人,應定期做肝功能檢查。
For patients with hepatic impairment, biliary abnormalities, or those concurrently using other antibiotics excreted via the same pathway, regular liver function tests are recommended.