適用於治療輕度至中度阿茲海默症 (Alzheimer's disease) 所引起的認知功能障礙。
Indicated for the treatment of mild to moderate cognitive impairment associated with Alzheimer's disease.
Donepezil 是一種乙醯膽鹼酯酯抑制劑，透過抑制乙醯膽鹼在中樞神經系統中的降解，增加乙醯膽鹼的濃度，從而改善阿茲海默症患者的認知功能。
Donepezil is an acetylcholinesterase inhibitor that increases acetylcholine concentration in the central nervous system by inhibiting its degradation, thereby improving cognitive function in patients with Alzheimer's disease.
口服給藥後，Donepezil 可迅速吸收，約3-4小時達到血漿峰值濃度。
其半衰期約為70小時，主要透過肝臟代謝，並經腎臟排泄。
After oral administration, Donepezil is rapidly absorbed, reaching peak plasma concentrations in approximately 3-4 hours. It has a half-life of approximately 70 hours, is primarily metabolized by the liver, and is excreted through the kidneys.
對 Donepezil 或其成分過敏的患者禁用。
Contraindicated in patients with hypersensitivity to Donepezil or any of its components.
Donepezil 在懷孕期間的使用應權衡利弊，除非潛在利益超過風險，否則不建議使用。
Donepezil should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
尚不清楚 Donepezil 是否會經由母乳排泄，因此哺乳婦女應謹慎使用。
It is not known whether Donepezil is excreted in human milk, so caution should be exercised when administered to nursing mothers.
常見副作用包括噁心、腹瀉、失眠、疲勞、肌肉痙攣等。
少數患者可能出現嚴重副作用如心律不整或胃腸道出血。
Common adverse effects include nausea, diarrhea, insomnia, fatigue, muscle cramps, etc. A small number of patients may experience severe side effects such as arrhythmias or gastrointestinal bleeding.
成人起始劑量為每天一次 5 mg，睡前服用。
根據臨床反應，可在4至6週後增加至 10 mg。
The initial dose for adults is 5 mg once daily, taken at bedtime. Based on clinical response, the dose may be increased to 10 mg after 4 to 6 weeks.
Donepezil 主要用於成人，對於小兒使用的劑量和安全性尚未確立。
Donepezil is primarily used in adults, and the dosage and safety for pediatric use have not been established.
No dosage adjustment is necessary for patients with renal impairment.
對於輕度至中度肝功能不全的患者，無需調整劑量。
嚴重肝功能不全患者應謹慎使用。
No dosage adjustment is necessary for patients with mild to moderate hepatic impairment. Use with caution in patients with severe hepatic impairment.