Rheumatic arthritis, certain leukemia, lymphoma, soft tissue inflammation, head injury, hemolytic anemia and other collagen diseases.
藥理
Dexamethasone is a synthetic adrenocortical steroid with potent anti-inflammatory effects in disorders of many organ systems, however, it lacks the sodium-retaining property of hydrocortisone
藥動學
Tmax, Oral tablet: 1 to 2 hours; Vd: 2 L/kg; Elimination Half Life: 1.88 to 2.23 hours
禁忌症
Systemic fungal infections, hypersensitivity, concomitant use of more than a single dose of Dexamethasone with Rilpivirine
懷孕分類
C [FDA]
哺乳分類
Compatible with breastfeeding. [WHO]; Infant risk cannot be ruled out. [MDX]
副作用
Common adverse effects include hypertension (13%), atrophic condition of skin, Cushing's syndrome, decreased body growth, at risk for infection, Abnormal vision (9% ), depression, euphoria, cardiomyopathy, hyperglycemia, osteoporosis.
劑量和給藥方法
Allergic condition: Adults: 0.75-9 mg/day PO depending on disease being treated and patient response; Pediatrics: 0.02 to 0.3 mg/kg/day (0.6 to 9 mg/m(2)/day) PO in 3 or 4 divided doses