高血壓 (diuretics) 利尿劑 (thiazide) Hypertension, edema due to congestive heart failure, hepatic cirrhosis, chronic renal disease and corticosteroid therapy
藥理
The primary action of the thiazides is to increase diuresis by blocking the reabsorption of sodium and chloride in the distal tubule and therefore an accompanying amount of water.
藥動學
Onset: approximately 1 to 2 hours
Peak Response: 3 to 6 hours
Duration: approximately 24 hr
Elimination Half-life: 2.3hr
禁忌症
Anuria, hypersensitivity to trichlormethiazide or other sulfonamides.
懷孕分類
C [FDA AUS]
哺乳分類
Infant risk cannot be ruled out
副作用
Nausea, flushing of face, hypokalemia, hyponatremia, hyperuricemia
劑量和給藥方法
2-4mg/day
小兒調整劑量
腎功能調整劑量
Dosage reduction may be required in patients with compromised renal function.