【藥品性質提示】 根據 2019 AGS Beers Criteria，本藥品為【潛在不適當用藥 (PIM)】，不建議用於老年人。

Estazolam is used in the short-term treatment of insomnia.

Estazolam is a benzodiazepine that acts as a CNS depressant and is used as a hypnotic agent.

Absorption- Oral: time to peak concentration, 2 h (0.5 h to 6 h). Distribution- Protein binding: 93%. Metabolism- extensive. Excretion- Fecal: 4%, Renal: less than 5% unchanged, Dialyzable: not determined. Elimination Half Life: 10 h to 24 h (mean); (59 y to 68 y): 18.4 h (13.5 h to 34.6 h)

Contraindicated for use during pregnancy; Concomitant use of ketoconazole or itraconazole

X [FDA]

Infant risk can not be ruled out.

Leukopenia, agranulocytosis, palpitation, arrhythmias, syncope, dizziness, headache, impaired coordination, constipation, vomiting, arthritis, myalgia, muscle spasm, anorexia

Insomnia: a signle dose of 1-4mg at bedtime. Premedication: Preoperative night: a single dose of 1-2mg at bedtime. Preoperation: a single dose of 2-4mg. Smaller or older, debilitated patients: 0.5mg initially. Maximum dose: a single dose of 6mg and daily dose of 8mg.