降血脂 (其他) Fenofibrate is used in the treatment of hyperlipoproteinemia, and to increase high-density lipoprotein cholesterol concentrations.

Fenofibrate may be more effective than clofibrate in lowering low-density lipoprotein (LDL)-cholesterol, and its efficacy can be enhanced by combination with other hypolipidemic agents that have a different mechanism of action.

Over 90% of micronized fenofibrate is absorbed when taken with meals; it is hydrolyzed to its active form, fenofibric acid, and extensively protein bound.

Preexisting gallbladder disease; hepatic dysfunction, including primary biliary cirrhosis and unexplained persistent liver function abnormality; hypersensitivity; severe renal dysfunction

C [FDA]

Infant risk has been demostrataed.

skin rash, transient elevations in serum transaminases have been reported.

Adults: 67mg PO QD with food, maximum 201mg/day; micronized capsules 67mg are bioequivalent to 100-mg non-micronized fenofibrate capsules; 200mg micronized capsule is equivalent to 3 capsules of 67mg micronized capsules.