藥碼
FLU22
藥名
Fluconazole 膠囊 50 mg
英文商品名
Fluene 膠囊 50 mg/Cap
中文商品名
膚黴克膠囊 50 mg
螢幕名
Fluene 膠囊 50mg
劑型
Cap
規格
Fluconazole 50mg/capsule
成分
藥理分類
Azole Antifungals
健保碼
AC41997100
ATC碼
適應症
念珠菌局部或全身感染，囊球菌感染，預防後天免疫缺乏症候群病人的黴菌感染。
藥理
Antifungal Agent: interferes with fungal cytochrome P450 activity, decreasing ergosterol synthesis and inhibiting cell membrane formation.
藥動學
Absorption: Well absorbed.
Distribution: Widely throughout the body with good penetration into CSF, eye, peritoneal fluid, sputum, skin, and urine.
Protein binding, plasma: 11% to 12%.
Bioavailability: >90%.
Half-life elimination: Adults: ~30 hours.
Time to peak, serum: 1 to 2 hours.
Excretion:V Urine (80% as unchanged drug).
Distribution: Widely throughout the body with good penetration into CSF, eye, peritoneal fluid, sputum, skin, and urine.
Protein binding, plasma: 11% to 12%.
Bioavailability: >90%.
Half-life elimination: Adults: ~30 hours.
Time to peak, serum: 1 to 2 hours.
Excretion:V Urine (80% as unchanged drug).
禁忌症
Hypersensitivity to fluconazole or any component of the formulation; coadministration with CYP3A4 substrates, which may lead to QTc prolongation.
懷孕分類
C
哺乳分類
副作用
>10%: headache (2% to 13%).
1% to 10%: skin rash (2%), abdominal pain (2% to 6%), diarrhea (2% to 3%), dysgeusia (1%), dyspepsia (1%), nausea (4% to 7%), vomiting (2% to 5%), dizziness (1%).
1% to 10%: skin rash (2%), abdominal pain (2% to 6%), diarrhea (2% to 3%), dysgeusia (1%), dyspepsia (1%), nausea (4% to 7%), vomiting (2% to 5%), dizziness (1%).
劑量和給藥方法
1. Cystococcal infection: 400 mg on the first day, then 200-400 mg/day for 6-8 weeks; Prevent recurrence of cystococcal meningitis in AIDS patients: 100 mg/day.
2. Invasive candidiasis infections: 400 mg on the first day, 200 mg/day; Maximum dose: 400 mg/day.
3. Oropharyngeal candidiasis: 50 mg/day for 7 to 14 days; Maximum dose: 100 mg /day.
4. Vaginal candidiasis: single dose: 150 mg.
5. Prevent fungal infection in cancer patients receiving chemotherapy or radiotherapy: 50 mg/day.
2. Invasive candidiasis infections: 400 mg on the first day, 200 mg/day; Maximum dose: 400 mg/day.
3. Oropharyngeal candidiasis: 50 mg/day for 7 to 14 days; Maximum dose: 100 mg /day.
4. Vaginal candidiasis: single dose: 150 mg.
5. Prevent fungal infection in cancer patients receiving chemotherapy or radiotherapy: 50 mg/day.
小兒調整劑量
≥ 1 year (normal renal function): 1-2mg/kg/day (skin infection); 3-6mg/kg/day (systemic infection).
腎功能調整劑量
1. No adjustment for vaginal candidiasis single-dose therapy.
2. Multiple dose: Initial dose: as adult; Maintenance dose: CrCl ≤50 mL/minute: Reduce dose by 50%.
2. Multiple dose: Initial dose: as adult; Maintenance dose: CrCl ≤50 mL/minute: Reduce dose by 50%.
肝功能調整劑量
安定性
藥袋資訊
臨床用途
黴菌感染
主要副作用
紅疹、腸胃不適、腹瀉、消化不良、頭痛、暈眩等
泡製方法
儲存方式
請置於 15-30℃ 乾燥處儲存
注意事項
其他說明
藥局 A1 | 藥庫 口C22
藥品外觀
顏色
13
10
形狀
13
剝痕
N
標記1
PZP
標記2
其他
健保藥價
17.4
自費價
23.14
仿單
資料庫
健保給付規定