megaloblastic anemia, anemia of nutritional origin, pregnancy, infancy or childhood.

Folic acid, after conversion to tetrahydrofolic acid, is necessary for normal erythropoiesis, synthesis of purine and thymidylates, metabolism of amino acids such as glycine and methionine, and the metabolism of histidine.

It is an incomplete therapy for pernicious anemia, it should not be employed because of the menace of neurological complications various types of leukemia.

A, but ranked as C in dose greater than 0.8mg/day. Folic acid deficiency may cause congenital malformations, especially neural tube defect.

Safe; folic acid is actively excreted in human breast milk. Maternal supplementation with the 0.5mg (RDA) for folic acid is recommended for those patients with inadequate nutritional intake.

Allergic sensitization

Folic acid deficiency: up to 1 mg/day; maintenance: 0.4 mg/day.