【藥品庫存】 本院含 metformin 成分 NDMA 致癌物檢驗結果為未檢出，請安心使用。更新日期：2020/9/14

糖尿病 (DPP4I / Metformin) Type 2 diabetes

Antidiabetic Agent

metformin: Onset of action: Within days; maximum effects up to 2 weeks Distribution: Vd: 654 ?? 358 L; partitions into erythrocytes; concentrates in liver, kidney, and GI tract Protein binding: Negligible Metabolism: Not metabolized by the liver Bioavailability: Absolute: Fasting: 50% to 60% Half-life elimination: Plasma: 4 to 9 hours; Blood ~17.6 hours Time to peak, serum: Immediate release: 2 to 3 hours; Extended release: 7 hours (range: 4 to 8 hours) Excretion: Urine (90% as unchanged drug; active secretion) vildagliptin: Absorption Tmax: 1.7 hours Bioavailability: 85% Effect of food: no effect on AUC; 19% decrease in Cmax; Tmax increased to 2.5 hours Distribution Protein binding: 9.3% Vd: 71 L Metabolism Possible hydrolysis via kidneys and dipeptidyl peptidase-4 Not metabolized via CYP450 enzymes Excretion Fecal: 15% Renal: 85%, 23% unchanged Renal clearance: 13 L/hr Dialyzable: No (hemodialysis), 3% removed Elimination Half Life: 3 hours

Known hypersensitivity to vildagliptin-metformin or any component of the formulation ESRD,eGFR<30ml/min/1.73m2 acute or chronic metabolic acidosis with or without coma acute complication: dehydration, severe infection, shock (acute kidney injury) heptic dysfunction breast feeding alcoholism, acute alcohol intoxication

Drug(Metformin) has been found to cross the placenta in concentrations which may be comparable to those found in the maternal plasma.Available evidence is is inadequate.

Should not use in breast-feeding women.Available evidence is is inadequate.

metformin >10%: Gastrointestinal: Diarrhea, nausea and vomiting, flatulence (4% to 12%) Infection: Infection (21%) Vildagliptin: Dizziness (1% to less than 10% ), Headache (0.1% to 12.9% ), Nasopharyngitis (3.5% to 13.2% )

initial dose :1 tablet twice daily daily maximum dose: metformin3000mg/vildagliptin100mg

GFR<30: Contraindication GFR30~44:metformin<1000mg daily/ vildagliptin<50mg daily GFR45~59:metformin<2000mg daily/ vildagliptin<50mg daily GFR60~89:metformin<3000mg daily/ vildagliptin<100mg daily

The manufacturer recommends avoiding metformin since liver disease is considered a risk factor for the development of lactic acidosis during metformin therapy

store in 30°C