藥碼
GEN03
藥名
Dobutamine 250 mg/20 mL/Vial
英文商品名
Gendobu 針 250 mg/20 mL/Vial
中文商品名
健多博注射液
螢幕名
Gendobu 針 250 mg/20 mL/Vial
劑型
Inj
規格
250mg/20ml/Vial
成分
藥理分類
Autonomic-β-Adrenergic Agonists
健保碼
AC42141238
ATC碼
適應症
| #建議持續輸注 (IV pump) 之高警訊藥品 |
治療心衰竭 Heart failure (Decreased cardiac output)
藥理
Dobutamine hydrochloride is a synthetic catecholamine and a direct-acting inotropic agent. It stimulates the beta-receptors of the heart which produces hypertensive, mild chronotropic, vasodilative, and arrhythmogenic effects.
藥動學
1. Distribution: Vd 0.2 L/kg
2. Metabolism: Liver and Tissues, a primary site of metabolism
3. Excretion: (Renal) 66%
4. Elimination Half Life: 1 to 2 minutes
2. Metabolism: Liver and Tissues, a primary site of metabolism
3. Excretion: (Renal) 66%
4. Elimination Half Life: 1 to 2 minutes
禁忌症
1. Hypersensitivity to corn or corn products (premix)
2. Hypersensitivity to Dobutamine
3. Subaortic stenosis, hypertrophic, idiopathic
2. Hypersensitivity to Dobutamine
3. Subaortic stenosis, hypertrophic, idiopathic
懷孕分類
B
哺乳分類
Infant risk cannot be ruled out.
副作用
Angina pectoris, Hypertension, Tachyarrhythmia, Headache
劑量和給藥方法
Acute decompensated heart failure:
(Continuous IV infusion) Initial 2-5 mcg/kg/minute; titrate based on clinical end point (eg, BP, end-organ perfusion); usual dosage range: 2-10 mcg/kg/minute; maximum 20 mcg/kg/minute
(Continuous IV infusion) Initial 2-5 mcg/kg/minute; titrate based on clinical end point (eg, BP, end-organ perfusion); usual dosage range: 2-10 mcg/kg/minute; maximum 20 mcg/kg/minute
小兒調整劑量
Hemodynamic support:
(Continuous IV or intraosseous infusion)
1. Dosage: Initial 0.5-1 mcg/kg/minute, titrate gradually every few minutes until desired response achieved
2. Rate: 2-20 mcg/kg/minute
(Continuous IV or intraosseous infusion)
1. Dosage: Initial 0.5-1 mcg/kg/minute, titrate gradually every few minutes until desired response achieved
2. Rate: 2-20 mcg/kg/minute
腎功能調整劑量
There are no dosage adjustments provided in the manufacturer's labeling.
肝功能調整劑量
There are no dosage adjustments provided in the manufacturer's labeling.
安定性
注射給藥指引
給藥途徑
IVFIV pump(持續靜脈輸注)、不建議 IV push
靜脈輸注液
D5W、NS、1/2NS、LR (仿單)
每瓶稀釋液體積
稀釋至50mL以上 (仿單)
注射濃度
4000 mcg/mL
給藥速率
詳見「劑量和給藥方法」。
安定性
注意事項
相容：bumetanide, cisatracurium, dexmedetomidine, diltiazem, dopamine, epinephrine, esmolol, fentanyl, Isoproterenol, ketamine, labetalol, lidocaine, lorazepam, manitol, milrinone, morphine, nicardipine, nitroglycerin, norepinephrine, octreotide, propofol, vasopressin
不相容：aminophylline, lansoprazole, pantoloc, sodium bicarbonate
完整資訊請見重症常用藥品靜脈相容性表
* NS：0.9%生理食鹽水； D5W：5%葡萄糖水； LR：乳酸林格氏液； 1/2NS：0.45%生理食鹽水； SWFI：注射用水
不相容：aminophylline, lansoprazole, pantoloc, sodium bicarbonate
完整資訊請見重症常用藥品靜脈相容性表
* NS：0.9%生理食鹽水； D5W：5%葡萄糖水； LR：乳酸林格氏液； 1/2NS：0.45%生理食鹽水； SWFI：注射用水
藥袋資訊
臨床用途
增強心肌收縮力
主要副作用
心跳快速、高血壓等
泡製方法
儲存方式
請置於 15-30℃ 乾燥處儲存
注意事項
其他說明
急首 e1 | 藥庫 注D11
藥品外觀
顏色
形狀
剝痕
標記1
標記2
其他
健保藥價
108
自費價
143.64
仿單
資料庫
健保給付規定