1.Cardiac dysrhythmia, Vagal reflex associated, surgically-induced or drug-induced - Surgical procedure 2.Premedication for anesthetic procedure

Antiasthma / Anticholinergic

Absorption Tmax, IM: 27.48 minutes Metabolism Liver: Via oxidation and hydrolysis Excretion Renal: 60% to 85% Elimination Half Life IM: 0.55 to 1.25 hours IV: 0.83 hours

Concomitant use of solid dosage forms of oral potassium chloride Gastrointestinal obstruction Glaucoma Hypersensitivity to glycopyrrolate, glycopyrronium, or any component of the product Intestinal atony in elderly or debilitated patients

Pregnancy Category Fetal risk cannot be ruled out

Breast Feeding Micromedex: Infant risk cannot be ruled out.

Common Gastrointestinal: Constipation , Vomiting , Xerostomia Renal: Urinary tract infectious disease Respiratory: Dyspnea , Nasal congestion , Nasopharyngitis, Upper respiratory infection. Serious Cardiovascular: Atrial fibrillation , Bradyarrhythmia, Cardiac arrest, Cardiac dysrhythmia, Tachycardia, Ventricular fibrillation Endocrine metabolic: Heat exhaustion, Malignant hyperthermia Gastrointestinal: Pseudo-obstruction of intestine Immunologic: Hypersensitivity reaction Neurologic: Nystagmus, Seizure , Somnolence Ophthalmic: Angle-closure glaucoma Respiratory: Paradoxical bronchospasm, Respiratory arrest Other: Angioedema

Cardiac dysrhythmia, Vagal reflex associated, surgically-induced or drug-induced - Surgical procedure 0.1 mg IV as a single dose, repeat every 2 to 3 minutes as needed Chronic obstructive pulmonary disease, Maintenance bronchodilation (Inhalation powder) 1 capsule (15.6 mcg glycopyrrolate) by oral inhalation twice daily at the same time every day; more than 1 capsule twice daily not recommended [3] (Inhalation solution) 1 vial (25 mcg glycopyrrolate) via oral inhalation twice daily at the same time every day; more than 1 vial twice daily is not recommended Premedication for anesthetic procedure 0.004 mg/kg IM 30 to 60 minutes before anesthesia or when the preanesthetic narcotic and/or sedative are administered

Intramuscular route Premedication for anesthetic procedure a) Usual dose (16 years or older): 0.004 mg/kg IM, given 30 to 60 minutes prior to anesthesia or at the time the preanesthetic narcotic and/or sedative are administered . b) Children 1 month to 2 years of age may need up to 0.009 mg/kg .

Dosage in Renal Failure A) Inhalation 1) (Inhalation powder and solution) Mild or moderate impairment: No dose adjustment required 2) (Inhalation powder) Severe impairment: Use only if potential benefits outweigh potential risks

Dosage in Hepatic Insufficiency A) Inhalation Powder and Solution 1) No dose adjustment required

store at controlled room temperature, between 20 and 25 degrees C (68 and 77 degrees F)