1. Symptomatic treatment of cognitive/intellectual or memory deficits (excluding Alzheimer disease and other dementias) 2. Adjunctive treatment of cortical myoclonus
藥理
Antimyoclonic, Miscellaneous; Nootropic
藥動學
Absorption:Bioavailability nearly 100%, Time to peak(serum) 30 minutes Distribution:Vd 0.6L/kg Excretion: urine(100%), half life 4-5 hours
禁忌症
Hypersensitivity to Piracetam, pyrrolidone, or any component of the formulation. End stage renal disease, Phenylketonurics, Intracranial hemorrhage.
Cognitive disorders: 1.2-4.8 g/day in 2-4 divided doses Cortical myoclonus, adjunctive: Initial 7.2 g/day in 2-3 divided doses; may increase total daily dose by 4.8 g every 3 to 4 days if needed; maximum daily dose: 24 g
小兒調整劑量
Children 8-13 years: 3.3 g/day in 2 divided doses
腎功能調整劑量
CrCl >80: Original dose, in 2-4 divided doses CrCl 50-79: 2/3 of original dose, in 2-3 divided doses CrCl 30-49: 1/3 of original dose, BID CrCl <30: 1/6 of original dose, QD CrCl <20(ESRD): Contraindication