【藥品性質提示】 ★LASA藥品：HEP08 Hepac 針 25,000IU/5mL/Vial (形音相似) 點擊看LASA藥品外觀比較圖

Venous catheter occlusion, Central; Prophylaxis

Heparin sodium, a glycosaminoglycan, inhibits the mechanisms that induce the clotting of blood and the formation of stable fibrin clots at various sites in the normal coagulation system. When heparin sodium is combined with antithrombin III (heparin cofactor), thrombosis is blocked through inactivation of activated Factor X and inhibition of prothrombin's conversion to thrombin. This also prevents fibrin formation from fibrinogen during active thrombosis.

Elimination Half Life

Severe thrombocytopenia. Uncontrolled active bleeding; except when due to DIC(Disseminated intravascular coagulation).

C

Heparin does not pass to baby in milk, so there are no possible side effects associated with breastfeeding while taking Heparin. However, it is important to talk with your doctor about the fact that you’re breastfeeding before starting treatment.

Common Hematologic: Thrombocytopenia (up to 30% ) Hepatic: Increased liver aminotransferase level Serious Hematologic: Hemorrhage (5% to 10% ), Heparin-induced thrombocytopenia (1% to 10% ), Heparin-induced thrombocytopenia with thrombosis (less than 1% ) Immunologic: Hypersensitivity reaction Neurologic: Non-traumatic spinal subdural hematoma

Venous catheter occlusion, Central; Prophylaxis Depending on the type of device, generally inject a quantity of heparin 10 or 100 units/mL sufficient to fill the entire device; replace the solution each time the device is used; institution specific protocols will vary. Venous catheter occlusion, Peripheral; Prophylaxis Inject 100 units/mL sufficient to fill the entire device (generally 1 to 3 mL); replace the solution each time the device is used; institution specific protocols will vary. Venous thromboembolism Initial, 80 units/kg IV bolus then 18 units/kg/hr, OR fixed dosing of 5000 units IV bolus followed by 1000 units/hr (guideline dosing). (Intermittent injection) Initial, 10,000 units IV bolus followed by 5000 to 10,000 units IV every 4 to 6 hours (manufacturer dosing). (Continuous infusion) Initial, 5000 units IV bolus followed by 20,000 to 40,000 units/24 hours (manufacturer dosing). (SubQ) Initial, 333 units/kg subQ followed by 250 units/kg subQ every 12 hours (manufacturer dosing). Venous thromboembolism; Prophylaxis Low-dose postoperative prophylaxis: 5000 units subQ 2 hours before surgery and 5000 units subQ every 8 to 12 hours for 7 days thereafter or until fully ambulatory. Total perfusion for open-heart surgery: 150 to 400 units/kg IV.

Atrial fibrillation - Thromboembolic disorder Initial, 75 to 100 units/kg IV bolus over 10 minutes [7] (Infants) Maintenance, 25 to 30 units/kg/hour; adjust to maintain aPTT of 60 to 85 seconds corresponding to anti-Factor Xa level of 0.35 to 0.7 units/mL [7] (Older than 1 year) Maintenance, 18 to 20 units/kg/hr; older children may require less heparin; adjust to maintain aPTT of 60 to 85 seconds corresponding to anti-Factor Xa level of 0.35 to 0.7 units/mL [7] Disseminated intravascular coagulation Initial, 75 to 100 units/kg IV bolus over 10 minutes [7] (Infants) Maintenance, 25 to 30 units/kg/hr; adjust to maintain aPTT of 60 to 85 seconds corresponding to anti-Factor Xa level of 0.35 to 0.7 units/mL [7] (Older than 1 year) Maintenance, 18 to 20 units/kg/hr; older children may require less heparin; adjust to maintain aPTT of 60 to 85 seconds corresponding to anti-Factor Xa level of 0.35 to 0.7 units/mL [7] Operation on heart Total perfusion for open heart surgery: 150 to 400 units/kg IV [9] Thrombosis, Non-Venous Catheter-Related; Prophylaxis (Neonates and children) Peripheral arterial catheters in situ: 0.5 units/mL at 1 mL/hr through the catheter by continuous infusion (guideline dose) [15] (Neonates) Umbilical artery catheter patency: 0.25 to 1 unit/mL low-dose infusion via the catheter; total dose 25 to 200 units/kg/day (guideline dose) [15] Venous catheter occlusion, Central; Prophylaxis Depending on the type of device, generally inject a quantity of heparin 10 or 100 units/mL sufficient to fill the entire device; replace the solution each time the device is used; institution specific protocols will vary; only preservative-free heparin flush may be used in neonates (manufacturer dosage) [13]. (Neonates) Central venous access device: 0.5 units/kg/hr by continuous infusion (guideline dosage) [15] Venous thromboembolism (Younger than 1 year) Loading, 75 units/kg over 10 minutes; maintenance, 28 units/kg/hour; target an aPTT corresponding to anti-factor Xa level of 0.35 to 0.7 units/mL (off-label dosing) [15] (Older than 1 year) Loading, 75 units/kg over 10 minutes; maintenance, 20 units/kg/hr; target an aPTT corresponding to anti-factor Xa level of 0.35 to 0.7 units/mL (off-label dosing) [15] Initial, 75 to 100 units/kg IV bolus over 10 minutes (manufacturer dosage) [7] (Infants) Maintenance, 25 to 30 units/kg/hr; adjust to maintain aPTT of 60 to 85 seconds corresponding to anti-Factor Xa level of 0.35 to 0.7 units/mL (manufacturer dosage) [7] (Older than 1 year) Maintenance, 18 to 20 units/kg/hr; older children may require less heparin; adjust to maintain aPTT of 60 to 85 seconds corresponding to anti-Factor Xa level of 0.35 to 0.7 units/mL (manufacturer dosage) [7] Venous thromboembolism; Prophylaxis Following cardiac catheterization: 100 unit/kg IV bolus, may require further doses in prolonged procedures (guideline dose) [15] Total perfusion for open-heart surgery: 150 to 400 units/kg IV

Mild to moderate renal dysfunction:Data not available Severe renal dysfunction:Use with caution

Use with caution

1) Storage a) Store heparin sodium injection at controlled room temperature, between 20 and 25 degrees Celsius (68 and 77 degrees Fahrenheit). b) Store heparin lock flush solution at 25 degrees Celsius (77 degrees Fahrenheit), with excursions permitted between 15 and 30 degrees Celsius (59 and 86 degrees Fahrenheit). Do not freeze . c) Store heparin sodium in 5% dextrose injection at room temperature, 25 degrees Celsius (77 degrees Fahrenheit), with brief excursions up to 40 degrees Celsius permitted. Avoid excessive heat and protect from freezing. There is no evidence for the degradation of heparin in sterile solutions of dextrose at pH 5 to 7 and temperature up to 37 degrees centigrade over 48 hours; however, anticoagulant activity has been shown to be reduced in ex vivo testing. d) Heparin diluted in 0.9% sodium chloride and stored in plastic (polypropylene) syringes was stable for up to 3 weeks without refrigeration [689]. Heparin once diluted should not be stored in glass, due to significantly lower heparin activity after storage in glass over a 2-hour period.