Postoperative ocular inflammation following cataract extraction (0.5% solution): Treatment of postoperative inflammation in patients who have undergone cataract extraction. Seasonal allergic conjunctivitis (ocular itching) (0.5% solution): Temporary relief of ocular itching caused by seasonal allergic conjunctivitis.
藥理
Inhibits prostaglandin synthesis by decreasing the activity of the enzyme, cyclooxygenase 1 and 2, which results in decreased formation of prostaglandin precursors.
藥動學
Absorption: Following instillation of ketorolac 0.5% ophthalmic drops 3 times/day, the mean plasma concentrations of ketorolac are ~4% to 8% of the minimum concentration observed following oral doses of 10 mg 4 times/day.
禁忌症
Hypersensitivity to ketorolac or any component of the formulation. Documentation of allergenic cross-reactivity for NSAIDs is limited. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty.
懷孕分類
C
哺乳分類
When administered orally, ketorolac enters breast milk; systemic exposure is decreased with ophthalmic administration (concentrations are ~4% to 8% of the minimum plasma concentration following an oral dose). The manufacturer recommends that caution be used when administering ketorolac ophthalmic to breast-feeding women.
副作用
>10%: Ophthalmic: Burning sensation of eyes (transient; Acular and Acular LS: 20% to 40%)
劑量和給藥方法
Postoperative ocular inflammation following cataract extraction (0.5% solution): Ophthalmic: Instill 1 drop into affected eye(s) 4 times daily beginning 24 hours after surgery; continue for 2 weeks. Seasonal allergic conjunctivitis (ocular itching) (0.5% solution): Ophthalmic: Instill 1 drop into affected eye(s) 4 times daily.