Prevention and treatment of damages due to faulty or deficient protein metabolism in chronic kidney disease in connection with a limited dietary protein intake of 40 g/day or less (adult).Usually this applies to patients whose glomerular filtration rate (GFR) is less than 25 mL/min.

Amino acid disorders

Ketosteril allows the intake of essential amino acids while minimising the aminonitrogen intake. Following absorption, the keto- and hydroxy- analogues are transaminated to the corresponding essential amino acids by taking nitrogen from non-essential amino acids,thereby decreasing the formation of urea by re-using the amino group.

Hypersensitivity to the active substances or to any of the excipients
Hypercalcaemia
Disturbed amino acid metabolism

There are no adequate data from the use of Ketosteril in pregnant women.

No experience has been made so far with the use during lactation.

Metabolism and nutrition disorders
Very rare: hypercalcaemia
If hypercalcaemia occurs, the intake of vitamin D should be reduced. In case of persisting hypercalcaemia, the dose of Ketosteril as well as the intake of any other calcium sources has to be reduced.

If not otherwise prescribed the dose for adults (70 kg body weight) is 4 to 8 tablets three times daily during meals. The tablets must not be chewed.

There is no experience in children.

Glomerular filtration rate (GFR) is below 25 mL/min, and concomitantly, dietary protein is restricted to 40 g/day or less (adult).