Absorption: Well absorbed from upper GI tract Distribution: Enters cells via active transport from extracellular fluid Excretion: Primarily urine; skin and feces (small amounts); most intestinal potassium reabsorbed
Adverse events have not been observed following use of potassium supplements in healthy women with normal pregnancies. Not recommanded for brestfeeding woman.(manufactuere's label) Use caution in pregnant women with other medical conditions (eg, preeclampsia; may be more likely to develop hyperkalemia) Use caution in pregnant women with other medical conditions (eg, preeclampsia; may be more likely to develop hyperkalemia)
哺乳分類
Potassium is excreted into breast milk.Not recommanded for brestfeeding woman.(manufactuere's label)
副作用
GI effects: May cause GI upset (eg, nausea, vomiting, diarrhea, abdominal pain, discomfort) and lead to GI ulceration, bleeding, perforation and/or obstruction.
Hyperkalemia:severe hyperkalemia may lead to muscle weakness/paralysis and cardiac conduction abnormalities (eg, heart block, ventricular arrhythmias, asystole).
劑量和給藥方法
Oral liquid preparations (not solid) should be used in patients with esophageal compression or delayed gastric emptying. Adult/Children:15mL per time TID~QID;mixed with water or juice,after meal,treatment should be going on until no hypokalemia.
Dose:
Normal daily requirement: Limited data available: Children and Adolescents: Oral: 1 to 2 mEq/kg/day
Hypokalemia, prevention for ongoing drug losses (eg, concurrent diuretic therapy):(Limited data available)
Children and Adolescents: Oral: 1~2 mEq/kg/day in 1 to 2 divided doses; maximum adult single dose: 20 mEq/dose
Hypokalemia,treatment; mild to moderate:Limited data available: Children and Adolescents: Oral: 2~5 mEq/kg/day in divided doses; not to exceed 1~2 mEq/kg as a single dose or 20 mEq (whichever is less) ; if deficits are severe or ongoing losses are great, IV potassium should be considered the preferred route of administration
小兒調整劑量
see adult dosing
腎功能調整劑量
Adult: no dosage adjustments (manufacturer's labeling). Children:no dosage adjustments (manufacturer's labeling). Reduce initial dose by at least 50% in adult patients with renal impairment (Kraft 2005). 3.Do not use with renal failure.
肝功能調整劑量
Adult: no dosage adjustments (manufacturer's labeling).Children: no dosage adjustments (manufacturer's labeling).