【藥品訊息】 Ladiol 凝膠 衛教單張

Abnormal vasomotor function (Moderate to Severe) - Menopause
Atrophic vulva (Moderate to Severe) - Menopause
Atrophy of vagina (Moderate to Severe) - Menopause
Decreased estrogen level, Secondary to hypogonadism, castration, or primary ovarian failureView additional information.
Menopause - Urethral atrophy (Moderate to Severe)
Postmenopausal osteoporosis; Prophylaxis
Prostate cancer, Advanced, Androgen-dependent; for palliation only

Estrogens regulate the transcription of a limited number of genes and act through binding to nuclear receptors in estrogen-responsive tissues. Estrogens also modulate the pituitary secretion of the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), through a negative feedback mechanism reducing the levels of these hormones seen in postmenopausal women. Estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites at the receptor level.

Absorption: Topical, gel: passive diffusion.
Metabolism:partially by P450 CYP3A4
Elimination Half Life:
Adults: Topical, gel, 10 to 36 hours.

X (FDA)

Milk effects are possible (MDX).
Maternal medication usually compatible with breastfeeding (AAP).
Avoid breastfeeding if possible. May inhibit lactation (WHO).

Common:
Gastrointestinal: Abdominal pain (Topical gel, 7.7%).
Neurologic: Headache (Topical gel 9.5%).
Reproductive: Breast tenderness (Topical gel, 2.5% to 8.8%, Disorder of menstruation, Pain of breast (Topical gel, 10.7%), Upper respiratory infection (Topical gel, 1.6% to 5.9%).