seasonal allergic rhinitis, perennial allergic rhinitis, and chronic urticaria.

Levocetirizine is the active levo form of cetirizine, mediated its principal anti-histaminic actions through selective inhibition of peripheral histamine H1-receptors, and its anti-inflammatory actions via inhibition of eosinophil migration and V-CAM 1 expressions, reducing mucosal inflammation.

Onset: within 1hr; oral bioavailability: ＞85%; protein binding: 98%; minimally metabolized by liver, at least 85% of the dose is excreted unchanged via urine.

History of hypersensitivity to levocetirizine or to any piperazine derivatives.Patients with severe renal impairment (ClCr＜ 10 ml/min)

B

not recommended

Dry mouth, headache, fatigue, and somnolence.

Allergic rhinitis, perennial:
Infants ≥ 6 months and Children ≤5 years: 1.25 mg once daily. Maximum daily dose: 1.25 mg/day.
6 to 11 years: 2.5 mg once daily. Maximum daily dose: 2.5 mg/day.
Hay fever and other respiratory allergies:
Children 2 to 5 years: 1.25 mg once daily. Maximum daily dose: 1.25 mg/day.
Children 6 to 11 years: 2.5 mg once daily. Maximum daily dose: 2.5 mg/day.
Urticaria, chronic:
Infants ≥ 6 months and Children ≤5 years: 1.25 mg once daily. Maximum daily dose: 1.25 mg/day.
Children 6 to 11 years: 2.5 mg once daily. Maximum daily dose: 2.5 mg/day.

Dose Adjustments according to ClCr:
ClCr＞50ml/min 5mg once daily,ClCr30-49ml/min 5mg once every 2 days,ClCr 29-10ml/min 5mg once every 3 days,ClCr＜10ml/min & hemodialysis patient : Contraindicated.