Tibolone is a synthetic steroidal agent with estrogenic, progestogenic, and androgenic activity. Tibolone has demonstrated efficacy in the treatment of menopausal symptoms and has prevented bone loss in postmenopausal patients.

Tibolone works by mimicking the activity of the female sex hormones, oestrogen and progesterone. It also has some male hormone (androgen) effects.

Hypersensitivity, breast cancer, estrogen-dependent neoplasms, cerebrovascular disease, coronary artery disease, thromboembolic disorders, history of cholestatic jaundice, hepatic tumors, abnormal vaginal bleeding

Contraindicated

Contraindicated.

headache, dizziness, edema and weight gain, and gastrointestinal disturbances. Vaginal bleeding is more common when the drug is given during the first year of menopause; potentially deleterious decreases in high-density lipoprotein (HDL) cholesterol and apolipoprotein A1 levels have been observed with tibolone. No coagulation effects were associated.

menopausal symptoms and prevention and treatment of postmenopausal osteoporosis: 2.5 mg PO QD