Loratadine is a long-acting tricyclic antihistamine with selective peripheral histamine H(1) receptor antagonistic activity. Pseudoephedrine sulfate is a decongestant that is an indirect, orally active sympathomimetic amine acting on the nasal mucosa
藥動學
禁忌症
hypersensitivity or idiosyncratic responses to adrenergic agents or similar drugs
hypersensitivity to loratadine or pseudoephedrine
MAOI use within 14 days
narrow-angle glaucoma
severe coronary artery disease
severe hypertension
urinary retention
懷孕分類
B
哺乳分類
Infant risk is minimal.
副作用
Gastrointestinal: Xerostomia (8% to 14% )
Neurologic: Insomnia (5% to 16% ), Somnolence (6% to 7% )
Psychiatric: Feeling nervous (3% to 5% )
Respiratory: Pharyngitis (3% to 5% )
劑量和給藥方法
(loratadine 5 mg/pseudoephedrine sulfate 120 mg) 1 tablet ORALLY every 12 h
小兒調整劑量
safety and efficacy not established in children less than age 12
腎功能調整劑量
GFR less than 30 mL/min: 5/120 mg, 1 tablet daily
肝功能調整劑量
use of loratadine/pseudoephedrine should be avoided
安定性
should be stored between 2 and 25 degrees Celsius or 36 to 77 degrees Fahrenheit. The unit-of-use packaging and unit dose-hospital pack should be kept in a dry place