Plasma expander transfusion; Adjunct - Traumatic shock

Dextran is colloid volume expander.

Distribution: Vd 6.5 liters.
Metabolism Sites and Kinetics: tissue.
Excretion: Renal Excretion (%) 50%.
Elimination Half-life: 41 minutes.
Hemodialysis: Dialyzable: No

Hypersensitivity to dextran or corn products, pulmonary edema, renal disease with severe oliguria or anuria, severe bleeding disorders, severe congestive heart failure.

C (FDA)

Infant risk cannot be ruled out (MDX), compatible with breastfeeding (WHO).

Blood coagulation disorder (prolonged coagulation times, thrombocytopenia, hematoma), transient liver enzyme elevations, alanine aminotransferase, flushing, erythema, or urticaria; a "strange" feeling, nephrotoxicity, pleural effusion, pulmonary edema.

Since dextrans are primarily eliminated by the kidney, dosage adjustment may be necessary in patients with renal insufficiency.