子癇症、子癇前症、妊娠毒血症、產科全身麻醉輔助；體內鎂離子缺乏時之補充。

Electrolyte solutions; Antiseizure Agent; Magnesium Salt

Onset of action: IM: 1 hour; IV: Immediate. Duration of antiseizure activity: IM: 3 to 4 hours; IV: 30 minutes. Distribution: Bone (50% to 60%); extracellular fluid (1% to 2%). Protein binding: 30%, to albumin. Excretion: Urine (as magnesium); feces (as unabsorbed drug).

Hypersensitivity to any component of the formulation; heart block; myocardial damage; IV use for preeclampsia/eclampsia during the 2 hours prior to delivery.

1.Magnesium crosses the placenta. Continuous maternal use for >5 to 7 days (in doses such as those used for preterm labor, an off-label use) may cause fetal hypocalcemia and bone abnormalities, as well as fractures in the neonate.
2.Magnesium sulfate may also be used prior to early preterm delivery for neuroprotection to reduce the risk of cerebral palsy; treatment may be of benefit when birth is anticipated before 32 weeks' gestation.

Flushing (IV; dose related), hypotension (IV; rate related), vasodilation (IV; rate related), hypermagnesemia.

Eclampsia/preeclampsia with severe features, seizure prophylaxis and treatment:
IV: Initial: 4 to 6 g loading dose over 15 to 30 minutes at onset of labor or induction/cesarean delivery, followed by 1 to 2 g/hr continuous infusion for at least 24 hours after delivery; Maximum infusion rate: 3 g/hr; Maximum dose: 40 g/day.
IM: Initial: 10 g loading dose administered as 5 g in each buttock at onset of labor or induction/cesarean delivery, followed by 5 g every 4 hours for at least 24 hours after delivery.
Hypomagnesemia :
Mild deficiency (serum magnesium >1.5 to 1.9 mg/dL): IV: 1 to 2 g over 1 to 2 hours; IM: 1 g every 6 hours for 4 doses.
Moderate deficiency (serum magnesium 1 to 1.5 mg/dL): IV: 2 to 4 g over 2 to 12 hours; IM: 1 g every 6 hours for 4 doses.
Severe deficiency (serum magnesium <1 mg/dL): IV: 4 to 8 g over 4 to 24 hours.

Hypomagnesemia (Infants, Children, and Adolescents):
IV: 25 to 50 mg /kg/dose every 6 hours for 2 to 3 doses; Maximum dose: 2,000 mg/dose.

Eclampsia/preeclampsia, seizure prophylaxis and treatment:
Severe renal impairment: IV: Initial: 4 to 6 g loading dose over 15 to 30 minutes, followed by 1 g/hour continuous infusion for at least 24 hours after delivery. Do not exceed 20 g during a 48-hour period.
Hypomagnesemia: Renal dysfunction: Reduce dose by 50%.

No dosage adjustment necessary.